DrakeWurrum
07-17-2004, 08:28 PM
Oh, and to you folks that say "Well doctors tell you to drink a glass of wine everyday" wine is bad for you, too.
http://www.advance-health.com/redwine.html
"When alcohol is consumed, the alcohol level in the blood
increases and
produces the intoxication effect. The body then begins
"detoxifying" or
metabolizing the alcohol. The first step is the conversion of alcohol
to
acetaldehyde by the enzyme alcohol dehydrogenase. This happens fairly
quickly in individuals who regularly consume alcohol. The second step
is the
conversion of acetaldehyde into acetate by the enzyme aldehyde
dehydrogenase. This process is a bit slower and leaves a quantity of
acetaldehyde in the system for several hours or longer. It is the
acetaldehyde that produces most of the undesirable toxic effects. The
acetate is metabolized to produce energy much like any other
carbohydrate.
Excess drinking can make you fat just as binging on pasta, ice cream
or any
other carbohydrate would.
Alcohol & Acetaldehyde Toxicity
Acetaldehyde, produced primarily in the liver, but also in other
organs to a lesser extent, readily binds to the walls of red blood
cells and
hitches a ride to all parts of the body including the brain. By
attaching
itself to the red blood cells, it makes them more rigid and prevents
them
from entering the smaller capillaries. (The smaller capillaries are
much
smaller than a red blood cell and the cell is forced to stretch,
elongate
and squeeze its way through.) This reduces the oxygen supply to most
of the
cells of the body including the brain. ( The Brain consumes 20% of
all the
oxygen we breathe). Acetaldehyde also combines with the hemoglobin in
the
red blood cells further reducing its ability to carry oxygen.
In addition to inducing hypoxia (oxygen starvation at the
cellular
level), Acetaldehyde reduces the ability of the protein tubulin to
assemble
into microtubules. Microtubules provide a structural support for the
neurons
and dendrites in the brain and actually transport neurochemicals
manufactured in the nerve cells to the dendrites, including genetic
material. Without the microtubules, the dendrites gradually atrophy
and die
off.
Acetaldehyde also induces deficiencies in B1 (Thiamine), B3
(Niacin),
NAD, Acetyl Coenzyme A, B5 (Pantothenic Acid), P5P
(Pyridoxal--5-Phosphate)
and inhibits Prostaglandin synthesis.
B1 deficiency can produce a syndrome characterized by mental
confusion, poor memory, poor coordination and visual disturbances.
B3 and NAD (an enzyme made from B3) are involved in the
metabolism of
sugars and fats into energy and are an important catalyst in the
production
of neurotransmitters, including seratonin, and activates the enzymes
alcohol
dehydrogenase and aldehyde dehydrogenase. Niacin deficiency symptoms
include
feeling fearful, apprehensiveness, worry, suspicion, depression,
headaches,
insomnia, depression, agitation and inability to concentrate.
B5 and its active form, Coenzyme A, is the most important
component of
the Krebs cycle which produces 90% of the body's energy. It is also
the
precursor of acetylcholine, an important neurotransmitter.
P5P is the major enzyme that is necessary to form virtually all
major
brain neurotransmitters. It also regulates the admission of magnesium
into
cells and thereby controls the excitability of nerve cells.
Acetaldehyde is also known to promote the production of opiate
like
chemicals in the body and promote the development of addiction to
toxic
substances.
... the point is that acetaldehyde is a very dangerous toxic
chemical
to have in the human body and brain. In addition to alcohol
consumption,
inhaling cigarette smoke or auto exhaust are other sources of
acetaldehyde.
The existence of certain strains of alcohol producing yeast in the GI
tract
can also be a source."
http://www.advance-health.com/redwine.html
"When alcohol is consumed, the alcohol level in the blood
increases and
produces the intoxication effect. The body then begins
"detoxifying" or
metabolizing the alcohol. The first step is the conversion of alcohol
to
acetaldehyde by the enzyme alcohol dehydrogenase. This happens fairly
quickly in individuals who regularly consume alcohol. The second step
is the
conversion of acetaldehyde into acetate by the enzyme aldehyde
dehydrogenase. This process is a bit slower and leaves a quantity of
acetaldehyde in the system for several hours or longer. It is the
acetaldehyde that produces most of the undesirable toxic effects. The
acetate is metabolized to produce energy much like any other
carbohydrate.
Excess drinking can make you fat just as binging on pasta, ice cream
or any
other carbohydrate would.
Alcohol & Acetaldehyde Toxicity
Acetaldehyde, produced primarily in the liver, but also in other
organs to a lesser extent, readily binds to the walls of red blood
cells and
hitches a ride to all parts of the body including the brain. By
attaching
itself to the red blood cells, it makes them more rigid and prevents
them
from entering the smaller capillaries. (The smaller capillaries are
much
smaller than a red blood cell and the cell is forced to stretch,
elongate
and squeeze its way through.) This reduces the oxygen supply to most
of the
cells of the body including the brain. ( The Brain consumes 20% of
all the
oxygen we breathe). Acetaldehyde also combines with the hemoglobin in
the
red blood cells further reducing its ability to carry oxygen.
In addition to inducing hypoxia (oxygen starvation at the
cellular
level), Acetaldehyde reduces the ability of the protein tubulin to
assemble
into microtubules. Microtubules provide a structural support for the
neurons
and dendrites in the brain and actually transport neurochemicals
manufactured in the nerve cells to the dendrites, including genetic
material. Without the microtubules, the dendrites gradually atrophy
and die
off.
Acetaldehyde also induces deficiencies in B1 (Thiamine), B3
(Niacin),
NAD, Acetyl Coenzyme A, B5 (Pantothenic Acid), P5P
(Pyridoxal--5-Phosphate)
and inhibits Prostaglandin synthesis.
B1 deficiency can produce a syndrome characterized by mental
confusion, poor memory, poor coordination and visual disturbances.
B3 and NAD (an enzyme made from B3) are involved in the
metabolism of
sugars and fats into energy and are an important catalyst in the
production
of neurotransmitters, including seratonin, and activates the enzymes
alcohol
dehydrogenase and aldehyde dehydrogenase. Niacin deficiency symptoms
include
feeling fearful, apprehensiveness, worry, suspicion, depression,
headaches,
insomnia, depression, agitation and inability to concentrate.
B5 and its active form, Coenzyme A, is the most important
component of
the Krebs cycle which produces 90% of the body's energy. It is also
the
precursor of acetylcholine, an important neurotransmitter.
P5P is the major enzyme that is necessary to form virtually all
major
brain neurotransmitters. It also regulates the admission of magnesium
into
cells and thereby controls the excitability of nerve cells.
Acetaldehyde is also known to promote the production of opiate
like
chemicals in the body and promote the development of addiction to
toxic
substances.
... the point is that acetaldehyde is a very dangerous toxic
chemical
to have in the human body and brain. In addition to alcohol
consumption,
inhaling cigarette smoke or auto exhaust are other sources of
acetaldehyde.
The existence of certain strains of alcohol producing yeast in the GI
tract
can also be a source."